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beBRCAware! Get Educated & Spread the Word on Ovarian Cancer & BRCA mutations

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I received $150 from AstraZeneca, and any opinions expressed by me are honest and reflect my actual experience. This is a sponsored post for SheSpeaks/AstraZeneca.

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Sadly,Who doesn’t know someone who has or is fighting a battle with Cancer. It seems everyone has someone they know. I lost my Godmother last year to Cancer and knowing how hard she fought and how hard it was for her is something that still affects me to this day. Although a cure still hasn’t been found there are many break through that can help others become aware of their risk of developing cancers like Ovarian and Breast Cancer.

What is a BRCA gene?
BRCA1 and BRCA2 are human genes involved with cell growth, cell division, and cell repair. Although they are most commonly associated with BReast CAncer, approximately 15% of women with ovarian cancer also have BRCA gene mutations.1,2

Who should get tested for the BRCA gene?
Clinical practice guidelines recommend that all women with epithelial ovarian cancer be considered for BRCA testing3. The test is simple and easy. A blood or saliva sample can be taken at your physician’s office or at a local lab. Medicare, Medicaid, and most private insurance carriers cover BRCA testing for women with a diagnosis of ovarian cancer. Certain mutations in BRCA1 or BRCA2 can affect how you and your physician choose to manage ovarian cancer.
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Important BRCA Facts:

  • Women with BRCA gene mutations have an increased risk of developing ovarian cancer.4
  • In the general population, 1.4 percent4 of women will be diagnosed with ovarian cancer, while up to 40 percent of women with BRCA 1/2 mutations will be diagnosed with ovarian cancer in their lifetime.5
  • An estimated 15% of ovarian cancers are linked to BRCA mutations.1,2
  • BRCA gene mutations can play a key role in serous ovarian cancer, the most common form of ovarian cancer.6
  • Nearly one half of women with ovarian cancer who are BRCA-positive have no significant family history of breast or ovarian cancer.7

Do you know a woman diagnosed with or at risk for ovarian cancer? Share the website myocjourney.com, which provides information about diagnosis, BRCA gene testing, treatment plans, and support networks that may be helpful to these women now and can help alert more women to what they need to know about BRCA and ovarian cancer. Fighting Cancer is one of the hardest battles a person can go through and sadly for many a diagnosis can be hard to swallow. Staying positive and proactive is very important and so very crucial for a successful outcome. Stay informed and most important know what your risks are!

 

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References:
1. Pal T, Permuth-Wey J, Betts JA, et al. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005;104(12):2807-2816.

2. National Cancer Institute. BRCA1 and BRCA2: Cancer risk and genetic testing. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA. Accessed June 2, 2014.

3. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Genetic/Familial High-Risk Assessment: Breast and Ovarian. Version 4;2013.2

4. National Cancer Institute. BRCA1 and BRCA 2: Cancer risk and genetic testing. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA. Last Accessed: October 30, 2014.

5. Petrucelli N, et al.,1998 Sep 4 [Updated 2013 Sep 26]. In: Pagon RA, Adam MP, Bird TD, et al., editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2014.

6. Wang ZC, et al. Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome. Clin Cancer Res. 2012;18:5806-5815.

7. Song H., The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population. Human Molecular Genetics 2014;23(17):4703-4709.

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3 Comments

  • Reply Jessica Lodge

    Since breast cancer runs in my family I got tested a few years ago. It was very easy to do and very educational. Until I got tested I didn’t even know about the ovarian cancer connection. I didn’t have the gene and that gave me a little piece of mind. I highly recommend doing the test if you’re in the risk category.

    March 17, 2015 at 12:00 pm
  • Reply Deborah D

    Thanks fo the reminder to get tested. This is a great cause.

    March 16, 2015 at 7:14 am
  • Reply David Fultner

    This is a great cause.

    March 14, 2015 at 10:09 pm
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